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The articles in this category describe CPU-controlled characters that are fought as much tougher enemies. This includes secret bosses (such as Q, Gouken and Akuma), end-of-level bosses (like Sodom, Rolento and Belger for Final Fight), or end-of-game bosses (like Vega, Balrog, Sagat and Bison for Street Fighter II).

Note that in the main series of Street Fighter games, every character can technically serve as a boss for another character. Characters in this category that appear in those games have served as bosses for most or all playable characters at least once.