Executed by performing two quarter-circle forward motions and pressing either all three punches or all three kicks, Oni unleashes a very powerful Hadoken which can be fired in multiple directions ("Ashes to ashes!"). If used in the air with all three punches, Oni will fire the projectile diagonally downwards. If used on the ground with all three kicks, Oni will fire the projectile up into the air instead.
If the base form's projectile connects point-blank on the first hit, an animation plays: Oni forces his opponent back with the first projectile as he prepares a second blast ("The gates of hell await!"). As the projectile lands, the force of the blow causes its energy to surge through them, shaping itself into Oni's kanji character.
If the Meido Gohado's full animation results in a KO, he will let out an evil laugh.
Messatsu-Gozanku (滅殺豪斬空, Messatsu Gou Zankuu, "Annihilating Great Slashing Air") is an air version of Meido Gohado. Oni shoots it downwards similar to the Tenma Gou Zanku. It does slightly more damage than the ground version without the animation.
Messatsu-Gotenha (滅殺豪天破, Messatsu Gou Tenha, "Annihilating Great Heaven Breaker") is an anti-air varient. Similar to Makoto's Fukiage, this attack can only hit opponents directly above Oni. It has slightly higher damage output than the regular Meido Gohado without the full animation.
In the DLC episode of Asura's Wrath "The Strongest vs. The Angriest", Oni performs it similarly to how it first appears Super Street Fighter IV: Arcade Edition. On the other hand, Asura can redirect the Meido Gohado and bounce it back at Oni.